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Mitoferrin1/2

WebTwo nuclear-encoded vertebrate mitochondrial high-affinity iron importers, mitoferrin1 (Mfrn1) and Mfrn2, have been identified in mammals. In mice, the gene encoding Mfrn1, … Web15 nov. 2024 · Interference of key regulators of mitochondrial lipid metabolism (e.g., ASCF2 and CS), iron homeostasis (e.g., ferritin, mitoferrin1/2 and NEET proteins), glutamine metabolism and other signaling pathways make a difference to ferroptotic sensitivity.

Overexpression of Drosophila mitoferrin in l(2)mbn cells results …

Web20 nov. 2024 · We thus conclude that mitochondrial Fe ion supply is an important player in neuronal energy metabolism and proper brain function and that the carrier mitoferrin-1 … Web20 nov. 2024 · Mitoferrin-2 1. Introduction Both mitochondrial impairment and impaired iron homeostasis have been associated with neurodegenerative diseases, such as Morbus Parkinson (PD), Alzheimer´s disease (AD) and amyotrophic lateral sclerosis (ALS) [ … mプラス 札幌 https://alex-wilding.com

Mitochondria regulation in ferroptosis - ScienceDirect

WebBackground: Here, we investigated whether iron mobilization enhanced photodynamic therapy (PDT)-induced cell killing.Results: Lysosomal iron release and mitochondrial iron uptake through mitoferrin-2 (Mfrn2) acted … WebSLC25A28 [mitochondrial inner membrane] Stable Identifier. R-HSA-1362394 WebZebrafish mitoferrin1 (mfrn1), one of two MRS3/4 orthologues, is essential for erythropoiesis, but little is known about the ubiquitously expressed paralogue mfrn2. In … mプラス 沖縄

Reactome Mitoferrin1,2 [mitochondrial inner membrane]

Category:Iron homeostasis of cyanobacteria: advancements in siderophores …

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Mitoferrin1/2

Mitoferrin1 Transgenic Zebrafish Line Serves as a Model to Study ...

Web1 feb. 2011 · Mitoferrin1 is 1 of 2 homologous mitochondrial iron transporters and is required for mitochondrial iron delivery in developing erythroid cells. We show that total … Web14 mrt. 2014 · Iron is imported into mitochondria via two transporters: mitoferrin-1 (MFRN1, SLC25A37) and mitoferrin-2 (MFRN2, SLC25A28). MFRN2 is expressed ubiquitously, whereas MFRN1 is specifically induced in differentiating erythroid cells ( 5, 6, 7 ).

Mitoferrin1/2

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Web22 sep. 2009 · By using positional cloning, we identified mitoferrin1 (mfrn1, slc25a37), a member of the mitochondrial solute carrier family, as the gene disrupted in frs mutants . … Web15 jul. 2009 · Zebrafish mitoferrin1 (mfrn1), one of two MRS3/4 orthologues, is essential for erythropoiesis, but little is known about the ubiquitously expressed paralogue mfrn2. In the present study we identified a single mitoferrin gene ( dmfrn ) in the genome of Drosophila melanogaster , which is probably an orthologue of mfrn2 .

Web2) We show, using a fluorescence-based assay that, when reconstituted in proteoliposomes, TMfrn1 has robust iron transport activity. ... Targeted deletion of the mouse mitoferrin1 gene: from anemia to protoporphyria. Blood. 2011; 117 (21310927): 5494-5502. 10.1182/blood-2010-11-319483. Web19 mei 2011 · Mitoferrin1 is 1 of 2 homologous mitochondrial iron transporters and is required for mitochondrial iron delivery in developing erythroid cells. We show that total …

WebResults: Lysosomal iron release and mitochondrial iron uptake through mitoferrin-2 (Mfrn2) acted synergistically to induce PDT-mediated and iron-dependent mitochondrial dysfunction and cell killing. Conclusion: Mfrn2 plays a critical … Web29 sep. 2024 · ATP-binding cassette subfamily B member 10 (Abcb10) is a mitochondrial ATP-binding cassette (ABC) transporter that complexes with mitoferrin1 and …

Web16 nov. 2008 · Abstract. We previously identified the mitochondrial solute carrier, Mitoferrin1 (Slc25a37, Mfrn1) as the principal mitochondrial iron importer essential for …

WebSLC25A37 [mitochondrial inner membrane] Stable Identifier. R-HSA-1362389 mプランニング 大阪WebZebrafish mitoferrin1 (mfrn1), one of two MRS3/4 ortho- cell lines, mbn-dmfrn cells had higher Fer1HCH (ferritin 1 logues, is essential for erythropoiesis, but little is known about heavy chain homologue) transcript and protein levels. RNA the ubiquitously expressed paralogue mfrn2. mプランニングWeb13 jun. 2024 · Cytosolic iron enters mitochondria by mitoferrin1/2 and is used for the synthesis of heme, formation of Fe-S clusters, and storage in mitochondrial ferritin (MtPt). The enhanced accumulation of labile iron in mitochondria induces … mプランニング 徳島WebMitoferrin1,2 [mitochondrial inner membrane] Stable Identifier. R-HSA-1362399. Type. Set [DefinedSet] Species. Homo sapiens ... mプルミエ 年齢層WebAs inferred from biochemical studies in yeast and phenotypic studies in mouse, Mitoferrin-1 (SLC25A37) and Mitoferrin-2 (SLC25A28) transport ferrous iron across the inner mitochondrial membrane. Mitoferrin-1 is essential for maintaining mitochondrial iron uptake in developing erythroid cells; mitoferrin-2 is ubiquitously expressed. mプランニング 淡路WebMitochondria regulation in ferroptosis Ferroptosis is recognized as a new form of regulated cell death which is initiated by severe lipid peroxidation relying on reactive oxygen … mプルミエ サイズ 38Web7 aug. 2024 · Mitochondrial iron import is essential for iron-sulfur cluster formation and heme biosynthesis. Two nuclear-encoded vertebrate mitochondrial high-affinity iron importers, … mプランニング 福岡