Klf2 and macrophage

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August undefined, 2024

WebOct 28, 2024 · KLF2 and MLKL overexpression was induced in macrophages using adenoviral constructs of KLF2 and MLKL (Ad-KLF2, Ad-MLKL, 1:100 MOI), empty vector as … WebApr 9, 2024 · Circ_0043256 upregulates KLF2 expression by absorbing miR-1206 to suppress the tumorigenesis of lung cancer. ... Kruppel-like factor 2 is involved in the enhanced secretion of MCP-1 by M2 macrophages loaded with oxidized LDL. KLF2 plays a critical role in dictating normal subset differentiation and functional reactivity of mature B …

Frontiers Krüppel-Like Factors in Metabolic Homeostasis and

WebApr 13, 2024 · KLF2 expression levels were found to be reduced in advanced cancer stages and grades, while positively correlated with the expression of estrogen receptor (ER), progesterone receptor (PR), and tumor size in breast cancer, according to the Tumor Immune Estimation Resource and Human Protein Atlas databases. Background: As a … WebNov 22, 2013 · Background Krüppel-like Factor 2 (KLF2) plays an important role in vessel maturation during embryonic development. In adult mice, KLF2 regulates expression of the tight junction protein occludin, which may allow KLF2 to maintain vascular integrity. Adult tamoxifen-inducible Krüppel-like Factor 4 (KLF4) knockout mice have thickened arterial … thomas and the garbage train uk

Myeloid KLF2 regulates a macrophage-enriched metabolic …

WebSep 1, 2009 · Recent studies have identified Hypoxia-inducible Factor 1alpha(HIF-1 alpha) as a key regulator of macrophage activation function. Using a combination of gain- and … WebKLF2 is a member of the Krüppel-like transcription factor family of proteins containing highly conserved DNA-binding zinc finger domains. KLF2 participates in the differentiation and … WebDec 28, 2024 · Given the role of Klf2 in cardiovascular development in mouse (Lee et al., 2006), we used the Transcription Activator-Like Effector Nuclease (TALEN) technology (Cermak et al., 2011) to mutate both klf2 paralogues in zebrafish (Figure 1A–B and Figure 1—figure supplement 1A–B), and identified a klf2a Δ10 allele (bns11) and a klf2b Δ8 allele … thomas and the ghost engine

Myeloid Krüppel-like factor 2 is a critical regulator of ... - Nature

Klf2 Kruppel-like factor 2 (lung) [ (house mouse)]

WebJul 20, 2015 · Macrophage inflammation is a key process of atherosclerosis. Macrophages ensure tissue cholesterol homeostasis by removing oxidized low-density lipoprotein … WebJan 24, 2024 · M2 macrophages. Thus, KLF2 inhibits inﬂammation-associated MiR-155 in ECs, which. is crucial for the selective growth and differentiation of macr ophages towards an anti- thomas and the golden eagle bookWebMar 28, 2024 · Excessive mitophagy and extensive immune infiltration were the primary factors affecting IRI. In particular, FUNDC1, SQSTM1, UBB, UBC, KLF2, CDKN1A, and GDF15 were the key influencing factors. In addition, B cells, neutrophils, T cells, and M1 macrophages were the key immune cells present in the IME after IRI. thomas and the great discovery ben

"WebKLF2orchestrates vascular homeostasis and serves as a key molecular switch between proinflammatory atheroprone and quiescent atheroresistant endothelial phenotype. This characteristic is attributed to its ability to activate atheroprotective and inhibit atherogenic endothelial transcription programs. " - Klf2 and macrophage

Klf2 and macrophage

WebApr 3, 2012 · KLF2 Deficiency Increases Macrophage Adhesion to Endothelial Cells The increase in atherosclerosis observed in myeloid KLF2-deficient hypercholesterolemic mice may be due to elevated macrophage inflammation and/or propensity for lipid accumulation in response to atherogenic lipoprotein stimulation. WebFeb 1, 2011 · To assess a causal role for KLF2 in regulation of M2 macrophage inflammatory responses, we performed small interfering RNA (siRNA) experiments to knockdown KLF2. Treatment of M2 macrophages with siRNA targeted to KLF2, led to a significant 35 ± 5% reduction in KLF2 gene expression as compared to mock treatment …

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WebApr 1, 2024 · Chromatin immunoprecipitation assays demonstrated that Klf4, Klf2, and Zfp148 separately bind autophagy genes in smooth muscle cells following elastase treatment. ... In immunostaining, macrophages, T cells, neutrophils, and neovessels were significantly reduced in aorta of spermidine-treated, as compared with vehicle-treated … WebNov 18, 2024 · KLF2 regulates metaflammation transcription in macrophages RNA-sequencing of bone marrow-derived macrophages (BMDMs) isolated from myeloid-specific KLF2 knockout (K2KO) and control (LysM)... We would like to show you a description here but the site won’t allow us.

WebApr 1, 2024 · KLF2 and NR4A1 are required for Ly6C − monocyte development and survival (109, 110). In Ly6C − monocytes, Nr4a1 is associated with a super-enhancer: a cluster of active transcriptional regulatory regions . KLF2 binds to this Nr4a1 super-enhancer and induces Nr4a1 expression. NR4A1 promotes the expression of monocyte-related … WebAug 28, 2008 · Because KLF2 has been shown to play a particularly potent role in inhibiting endothelial cell and monocyte/macrophage activation, we focused our mechanistic studies on these 2 cell types. The key observation highlighted by our study relates to the role of KLF2 in monocyte/macrophage biology.

WebMar 1, 2012 · KLF2 regulates macrophage activation by inhibiting NF-κB/HIF-1α activities ( 25 ). IL-4 also induces c-Myc activity in human macrophages ( 26 ), which controls genes of M2 activation ( Scarb1, Alox15, and Mrc1) as well as STAT6 and PPARγ activation ( 26 ). Figure 1 Mechanisms of macrophage polarization. WebRecent studies have linked Kruppel-like factors (KLFs) to the biology of macrophage activation and polarization ( 14. , 15. ). The initial link of this gene family to myeloid …

WebMyeloid KLF2 regulates a macrophage-enriched metabolic network and is responsive to metaflammatory stress a Gene-set enrichment analysis of bone marrow-derived macrophages (BMDMs) from...

WebMar 26, 2024 · Macrophage KLF4 expression was robustly induced in M2 macrophages and strongly reduced in M1 macrophages, observations that were recapitulated in human … udemy accounts for freeWebFeb 5, 2024 · KLF2 is a member of the Kruppel-like transcription factor family of proteins containing highly conserved DNA-binding zinc finger domains. KLF2 participates in the differentiation and regulation of the functional activity of monocytes, T lymphocytes, adipocytes, and vascular endothelial cells. The activity of KLF2 is controlled by several … udemy account costWebRecent studies have linked Kruppel-like factors (KLFs) to the biology of macrophage activation and polarization ( 14. , 15. ). The initial link of this gene family to myeloid biology was the identification of KLF2 as a tonic repressor of macrophage pro-inflammatory activation ( 14. ). udemy accountsWebThe transcription factor Krüppel-like factor-2 (KLF2), and to a lesser extent KLF4, control the expression of many genes within the macrophage clearance program. These characteristics include high expression of receptors for apoptotic cells such as Tim4, but low expression of toll-like receptor (TLR)9 and reduced TLR responsiveness to nucleic ... udemy account businessWebApr 11, 2024 · Cd74, the macrophage migration inhibitory factor (MIF) receptor, is enhanced in the KC of systemic sclerosis and may be associated with the proinflammatory pathways [33]. ... Klf2, Klf4, and Klf6 were found to be the key TFs in Col17a1 hi PBC, while Cux1, Dlx3, and Lef1 were the predominant TFs in Cux1 hi PBC. thomas and the great discovery trackmasterWebJan 6, 2024 · Thus, evolution has fashioned macrophages to orchestrate a coordinated inflammatory and hypoxic gene program to mount an effective immune response. Here, … udemy acsWebAug 28, 2008 · KLF2 is a key regulator of endothelial and monocyte/macrophage proinflammatory action. 1,2 In endothelial cells, KLF2 expression is induced by laminar … thomas and the ghost train