Cisplatin pk

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August undefined, 2024

WebPurpose: Cisplatin and carboplatin are frequently used drugs in the treatment of pediatric hepatoblastoma. Dosing guidelines for these drugs in children requiring peritoneal dialysis are lacking. Here, we describe the case of a 3-year-old boy with pre-existing end-stage renal disease on peritoneal dialysis, requiring treatment with cisplatin and carboplatin for … WebJun 15, 1987 · The plasma clearance of free cisplatin (26.1 ml/min/kg) was significantly greater than that of either Carboplatin (10.3 ml/min/kg) or insulin (10.1 ml/min/kg). The main route of excretion of the two platinum complexes was via the urine, with 80-90% of Carboplatin and 43-48% of cisplatin being excreted within 4 hr.

Cisplatin and carboplatin pharmacokinetics in a pediatric

WebDec 31, 2008 · The cisplatin dose was 75 mg/m 2 for all cohorts and the pemetrexed dose was increased in increments of 100 mg/m 2 for subsequent cohorts. Treatment and dose escalation scheme. Pemetrexed and cisplatin were administered on day 1 of a 21-d cycle as i.v. infusions of 10 and 60 min, respectively. WebApr 1, 2000 · Oxaliplatin(cis-[(1R,2R)-1,2-cyclohexanediamine-N,N′]oxalato (2-)-O,O′] platinum; Eloxatine; Fig. 1) is a novel platinum coordination complex recently approved in Europe, Asia, and Latin America for the treatment of metastatic colorectal carcinoma in combination with fluoropyrimidines.Oxaliplatin is more potent than cisplatin in vitro, … inclination\\u0027s vx

C57BL/6 mice require a higher dose of cisplatin to induce …

WebMar 1, 1998 · Although cisplatin has been used extensively for the treatment of solid tumors, the best administration schedule has not been decided yet. The majority of … WebNov 18, 2024 · Individual pharmacokinetics (PK) parameters of Cisplatin were identified using a Bayesian approach. Nephrotoxicity and ototoxicity were considered as typical Cisplatin-related toxicities according to Common Terminology Criteria for Adverse Events (CTCAE) standards. WebConclusion: TGF-β induced TMEPAI contributes to the reduced response of TNBC treatment to doxorubicin and paclitaxel, but minimal on cisplatin and bicalutamide. Further study is needed to confirm our findings in other growth factor-induced cells, as well as in in vivo model. Keywords: TMEPAI, TGF-β, doxorubicin, paclitaxel. inboxer vs outboxer

The effect of different doses of cisplatin on the pharmacokinetic ...

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WebJun 21, 2024 · Cisplatin was administered at a dose of 80 mg per square meter of body-surface area in a continuous intravenous 6-hour infusion for four preoperative and two postoperative courses at 14-day... WebFinally, we discovered that integrin α6β4 preferentially activated DNA-PK, facilitated DNA-PK-p53 and p53-53BP1 complex formation in response to cisplatin and required DNA-PK to enhance ATM, 53BP1 and p53 activation as well as cisplatin sensitivity. In summary, we discovered a novel function of integrin α6β4 in promoting cisplatin ... inclination\\u0027s vwWebSerial plasma samples for PK analysis were obtained at intervals before and after the administration of capecitabine and cisplatin on Day 1. Results: Twenty-two patients were enrolled in this PK study: eight in the HXP arm and 14 in the XP arm. All blood samples were available for PK analysis. inboxerror 0x8007274d

"WebFurther, cisplatin (CDDP)-resistant FaDu cells displayed stem-like features and higher CD44, ABCB1 and ADAM17 expression. Higher autophagic flux and mitophagy were observed in resistant FaDu cells as compared to parental cells, and inhibition of autophagy led to the decrease in stemness, restoration of mitochondrial proteins and reduced ... " - Cisplatin pk

Cisplatin pk

Integrin α6β4 signals through DNA damage response pathway to …

WebAdministration of a nephrotoxic drug such as cisplatin can be used to cause renal dysfunction as an approach to mimic human serum levels of renally excreted drugs. We aimed to determine the dose of cisplatin that did not affect the survival rate of mice and to achieve human-like serum concentrations of cefepime. WebNational Center for Biotechnology Information

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WebCisplatin, a class of platinum-containing anticancer drugs for the treatment of solid tumors, is a substrate of OCT2 and MATE1/MATE2-K. OCT2 is expressed in the basolateral …

WebThe pharmacokinetics of cisplatin and its cytotoxic hydrolysis product cis-diammineaquachloroplatinum(II) ion (monohydrated complex) were investigated in seven … WebWe aimed to evaluate cisplatin pharmacokinetics (PK) and the exposure to unbound cisplatin in SCLC patients using the informative priors, and assess the relationship between the cisplatin...

WebVorbeugung der durch Cisplatin-Chemotherapie induzierten Ototoxizität; Neue Medikamente zur Zulassung empfohlen: Bimervax (COVID-19-Impfstoff [rekombinant, adjuvant]): ist als Booster für die aktive Immunisierung zur Vorbeugung von COVID-19 bei Personen ab 16 Jahren indiziert, die zuvor einen mRNA-COVID-19-Impfstoff erhalten … WebAug 20, 2024 · Population pharmacokinetic (PK) models for cisplatin are usually one- or two-compartment models and BSA is typically reported as a significant covariate …

WebApr 4, 2024 · PK was determined by LC-MS/MS, and PD included methemoglobin levels at 4 h post dose. Within patient PK variability after IV and PO dosing and PO bioavailability were calculated. Results: PK data were available for 10 patients at 100 (the MTD) and 150 mg. PO parameter values were T max 1.3 h, t 1/2 1.4 h, CL/F 104 L/h, and V z /F 214 L.

WebJan 27, 2024 · Fig. 4: Prediction of cisplatin PK and PD parameters using the multi-organ-chip IVIVT system. a, The fluidic coupling path of the bone marrow, liver and kidney chips linked to the AV reservoir in ... inboxfitness promotional codesWebOct 7, 2024 · Cisplatin is one of the most widely used chemotherapeutic drugs in the treatment of a wide range of pediatric and adult malignances. However, it has various side effects which limit its use. Cisplatin mouse models are widely used in studies investigating cisplatin therapeutic and toxic effects. inboxes definitionWebCarboplatin shares some of the therapeutic advantages of cisplatin, but without a significant incidence of the dose-limiting neurotoxicity and nephrotoxicity which is experienced with cisplatin. However, its use is associated with dose-limiting bone marrow suppression. Carboplatin is present in the blood as 3 distinct species. inboxgatewayWebDec 15, 2012 · OSTI.GOV Journal Article: Cisplatin Pharmacokinetics in Nontumoral Pig Liver Treated With Intravenous or Transarterial Hepatic Chemoembolization Cisplatin Pharmacokinetics in Nontumoral Pig Liver Treated With Intravenous or Transarterial Hepatic Chemoembolization Full Record Related Research Abstract inclination\\u0027s wWebFor intraperitoneal therapy, paclitaxel or cisplatin was reconstituted in 2 liters of warmed normal saline and infused as rapidly as possible through an implantable peritoneal catheter.... inboxexpert xmr3.comWebCisplatin for injection is indicated for the treatment of advanced bladder cancer. 2 DOSAGE AND ADMINISTRATION . 2.1 Hydration and Anti-Emetic Treatment . Patients treated … inboxguardWebApr 14, 2024 · Moreover, in cisplatin-induced renal injury models, they also reduced serum blood urea nitrogen (BUN) and creatinine levels to different degrees, the best of which was 6-methylflavone. The pharmacophore model clarified that the aromatic ring, hydrogen bond acceptors, and hydrogen bond donors might play a vital role in the inhibitory effect of ... inclination\\u0027s vy